Education & Career

• 1982 B.S. Callege of pharmacy, Seoul National University, Korea
  
• 1985 M.S. Callege of pharmacy, Seoul National University, Korea
  
• 1989 Ph.D. Callege of pharmacy, University of Tokyo, Japan
  
• 1994 Guest Researcher Nathional Cancer Institute, NIH, U.S.A
• 2007-2009 Dean, Collage of Pharmacy

Research Areas

1. Functional Analysis of Sphingolipid metabolites
   
2. Regulation and Evaluation of Life-style Disease by S1P

Selected Publications

1. Development and validation of rapid and simultaneous method for determination of 12 hair-growth compounds in adulterated products by UHPLC-MS/MS. Park HN, Lee JH, Park SK, Baek SY, Lee YM, Kang H. Forensic Sci Int. 2018 Mar;284:129-135.
2. Cellular and metabolic Basis for the Ichthyotic Phenotype in NIPAL4 (Ichthyin)-Deficient Canines. Mauldin EA, Crumrine D, Casal ML, Jeong S, Opálka L, Vavrova K, Uchida Y, Park K, Craiglow B, Choate KA, Shin KO, Lee YM, Grove GL, Wakefield JS, Khnykin D, Elias PM. Am J Pathol. 2018 Jun;188(6):1419-1429.
3. The effect of sphingosine-1-phosphate on bone metabolism in humans depends on its plasma/bone marrow gradient. Kim BJ, Shin KO, Kim H, Ahn SH, Lee SH, Seo CH, Byun SE, Chang JS, Koh JM, Lee YM. J Endocrinol Invest. 2016 Mar;39(3):297-303.
4. ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. Park K, Ikushiro H, Seo HS, Shin KO, Kim YI, Kim JY, Lee YM, Yano T, Holleran WM, Elias P, Uchida Y. Proc Natl Acad Sci U S A. 2016 Mar 8;113(10):E1334-42.

Education & Career

• 2003 – 2009 : Ph.D. College of pharmacy, Seoul National University
• 1997 - 2003 : B.S. College of pharmacy, Seoul National University
• Mar 2017 – Present : Assistant Professor, College of Pharmacy, Chungbuk National University
• Mar 2015 – Feb 2017 : Research Professor, Konkuk University Glocal Campus
• Jan 2011 – Feb 2015 : Postdoctoral Researcher, Vanderbilt University Medical Center
• Mar 2009 – Dec 2010 : Postdoctoral Researcher, College of pharmacy, Seoul National University

Research Areas

1. Structural Studies on membrane & soluble proteins

   
   

   1.1 Caveolin 3
   

   1.2 CD44
   

2. Engineering of Antibody Drug
   

   
   

3. Structure based Drug Design
   

Selected Publications

1. KS Jo, JH Kim, KS Ryu, JS Kang, CY Wang, YS Lee, MD Seo, YH Lee, HS Won (2019) Unique Unfoldase/Aggregase Activity of a Molecular Chaperone Hsp33 in its Holding-Inactive State, Journal of Molecular Biology, 431, 1468-1480
2. KS Jo, KS Ryu, HW Yu, SN Lee, JH Kim, EH Kim, CY Wang, CG Kim, CG Kim, HS Won (2018) Structural assessment of the tetramerization domain and DNA-binding domain of CP2c, J. Kor. Magn. Reson, 22, 119-124
3. DW Sim, J Song, JH Kim, JK Lee, DY Chung, KS Jo, CG Kim, MD Seo, HC Kang, JC Paneng, YP Kim, HW Won (2018) Enhancing bacterial production of a recombinant cetuximab-Fab by partial humanization and its utility for drug conjugation, Process Biochemistry 69, 123-130
4. KS Jo, DW Sim, EH Kim, DH Kang, YB Ma, JH Kim*, HS Won*, (2018) Backbone NMR Assignments of a Putative p53-binding Domain of the Mitochondrial Hsp40, Tid1 J. Kor. Magn. Reson, 22, 64-70 (* co-corresponding authors)
5. JH Kim, H-S Won, WS Yoon, SH Seok, BJ Jung, SN Lee, DW Sim, MD Seo (2018) Crystal Structure of Shigella flexneri SF173 Reveals a Dimeric Helical Bundle Conformation, crystals 8(2) 97
6. DW Sim, Z Lu, HS Won, SN Lee, MD Seo, BJ Lee, JH Kim (2017) Application of Solution NMR to Structural Studies on α-Helical Integral Membrane Proteins, Molecules 22(8) E1347
7. DW Sim*, JW Choi*, JH Kim*, KS Ryu, M Kim, HW Yu, KS Jo, EH Kim, MD Seo, YH Jeon, BJ Lee, YP Kim, HS Won (2017) C-terminal dimerization of apo-cyclic AMP receptor protein validated in solution, FEBS letters 591(7), 1064-1070 (* co-first authors)
8. JH Kim, B Park (2017) Triptolide blocks the STAT3 signaling pathway through induction of protein tyrosine phosphatase SHP-1 in multiple myeloma cells, International Journal of Molecular Medicine 40, 1566-1572
9. SH Lee, DW Sim, EH Kim, JH Kim*, and HS Won* (2017) Backbone NMR Assignments and Secondary Structure Determination of a Cupin-family Protein YaiE from Escherichia coli, J. Kor. Magn. Reson, 21, 50-54 (* co-corresponding authors)
10. DW Sim*, JH Kim*, HY Kim*, JH Jang, WC Lee, EH Kim, PJ Park, KH Lee, HS Won (2016) Structural identification of the lipopolysaccharide‐binding capability of a cupin‐family protein from Helicobacter pylori, FEBS letters 590(17), 2997-3004 (* co-first authors)
11. JH Kim, DW Sim, DS Park, TG Jung, SH Lee, TH Oh, JR Ha, SH Seok, MD Seo, HC Kang, YP Kim, HS Won (2016) Bacterial production and structure-functional validation of a recombinant antigen-binding fragment (Fab) of an anti-cancer therapeutic antibody targeting epidermal growth factor receptor, Applied Microbiology and Biotechnology 100(24), 10521-10529
12. JH Kim, JP Schlebach, ZL D Peng, KC. Reasoner, CR. Sanders (2016) A pH-mediated topological switch within the N-terminal domain of human Caveolin-3, Biophysical Journal 110(11) 2475-2485
    
13. JP Schlebach ,PJ Barrett, CA Day, JH Kim, AK Kenworthy , CR Sanders (2016) Topologically diverse human membrane proteins partition to liquid-disordered domains in phase-separated lipid vesicles, Biochemistry 55(7) 985-8
    
14. JH Kim*, YC Kim*, B Park (2016) Hispolon from Phellinus linteus induces apoptosis and sensitizes human cancer cells to the tumor necrosis factor-related apoptosis-inducing ligand through upregulation of death receptors, Oncology Reports 35(2) 1020-6 (* co-first authors)
    
15. B Kim*, JH Kim*, B Park (2016) Pomolic acid inhibits invasion of breast cancer cells through the suppression of CXC chemokine receptor type 4 expression, J Cell Biochem 117(6) 1296-307 (* co-first authors)
    
16. DW Sim, YS Lee, MD Seo, HS Won, and JH Kim (2015) A simple guide to the structural study on membrane proteins in detergents using solution NMR, J. Kor. Magn. Reson, 19(3) 137-142
    
17. KY Lee, JH Kim, YJ Bae, and BJ Lee (2015) pH effect on the structure of reduced NifU–like protein from Helicobacter pylori, J. Kor. Magn. Reson, 19(3) 106-111
    
18. KY Lee, KY Lee, JH Kim, IG Lee, SH Lee, DW Sim, HS Won, BJ Lee (2015) Structure–based functional identification of Helicobacter pylori HP0268 as a nuclease with both DNA nicking and RNase activities, Nucleic Acids Research 43(10), 5194-207
    
19. IG Lee, SJ Lee, S Chae, KY Lee, JH Kim, and BJ Lee (2015) Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin (TA) system: implications into the design of novel antimicrobial peptides, Nucleic Acids Research 43(15) 7624-37
    
20. CL Deatherage, Z Lu, JH Kim, and CR Sanders, (2015) Notch transmembrane domain: secondary structure and topology, Biochemistry 54(23) 3565-8
    
21. JH Kim, D Peng, JP Schlebach, A Hadziselimovic, CR Sanders, (2014) Modest effects of lipid modifications on the structure of Caveolin-3, Biochemistry 53(27) 4320-2,
    
22. D Peng, JH Kim, BM Kroncke, CL Law, Y Xia, KD Droege, WD Van Horn, CG Vanoye, CR Sanders, (2014) Purification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channel, Biochemistry 53(12) 2032-42